New Preprint: Isolating the sources of heterogeneity in nanoparticle-cell interactions

Experiments show that interactions between nanoparticles and cells are heterogeneous – there is a distribution of nanoparticle-cell uptake even when the nanoparticles being delivered are nominally identical. This is important because delivering the appropriate dose of a nanomedicine, in part, determines its efficacy.

Significantly, this heterogeneity changes over time following exposure of nanoparticles to cells. Our new paper uses a combination of modelling and experimental work to figure out why heterogeneity in nanoparticle-cell interactions appears to change over time, and to determine what are the potential sources of heterogeneity underlying this phenomenon.

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Our study, led by Dr Stuart Johnston, shows that the key mechanisms driving early-time interactions and late-time interactions are different, and this transition between mechanisms makes it appear that heterogeneity changes over time. Read more about it here:

S.T. Johnston, M. Faria, E.J. Crampin
Isolating the sources of heterogeneity in nanoparticle-cell interactions
bioRXiv:10.1101/817569

This work was in part funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036).

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