Author Archives: Edmund Crampin

Assessing detection of calcium release sites from live cell imaging data

Our latest paper reports on computational modelling to simulate calcium release within realistic cardiomyocyte cell geometries to determine how cellular architecture can affect what you see under the microscope. Read more in our paper: D. Ladd, A. Tilunaite, H.L. Roderick, … Continue reading

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Two new papers on bio-nano interactions

Announcing two new papers, recently published, arising from our collaborations with the Caruso and Kent groups at UniMelb in the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CBNS)! M. Faria, K.F. Noi, Q. Dai, M. Björnmalm, S.T. … Continue reading

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Want to do a PhD in Computational Cell / Systems / Synthetic Biology?

Join Prof Michael Stumpf, Prof Karin Verspoor, Dr Heejung Shim and me at the University of Melbourne and learn how to model whole cells as part of a multidisciplinary & supportive research team! Contact me at edmund.crampin@unimelb.edu.au to find out more.

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Pair correlation functions for environments with obstacles – new paper published in Physical Review E

Pair correlation is used widely across biology, ecology and physics, as well as in other areas, to obtain estimates of spatial structure. Environments with obstacles or voids that inhibit and alter the motion of individuals within that environment can give rise to spurious … Continue reading

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Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration – published in Scientific Reports

Our new paper “Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration” is now published at Scientific Reports. This is work by Ivo Siekmann which arose from a fantastic collaboration … Continue reading

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New Preprint: Modelling the interaction between RyR and IP3R calcium release in cardiomyocytes

Calcium signalling plays a central role in heart cells. With each heart beat, calcium is released from intracellular stores (SR) via RyR channels to trigger contraction. However, calcium signalling is also implicated in controlling the growth of heart cells, as … Continue reading

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New Preprint: Development of a 3D computational model of calcium release in heart cells

Our new preprint on bioRXiv describes the development of a structurally realistic 3D computational model of a cardiomyocyte which we use to simulate reaction-diffusion of calcium release from RyR clusters during the initial phase of the cardiac calcium transient. We use … Continue reading

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