Author Archives: Edmund Crampin

Pair correlation functions for environments with obstacles – new paper published in Physical Review E

Pair correlation is used widely across biology, ecology and physics, as well as in other areas, to obtain estimates of spatial structure. Environments with obstacles or voids that inhibit and alter the motion of individuals within that environment can give rise to spurious … Continue reading

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Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration – published in Scientific Reports

Our new paper “Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration” is now published at Scientific Reports. This is work by Ivo Siekmann which arose from a fantastic collaboration … Continue reading

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New Preprint: Modelling the interaction between RyR and IP3R calcium release in cardiomyocytes

Calcium signalling plays a central role in heart cells. With each heart beat, calcium is released from intracellular stores (SR) via RyR channels to trigger contraction. However, calcium signalling is also implicated in controlling the growth of heart cells, as … Continue reading

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New Preprint: Development of a 3D computational model of calcium release in heart cells

Our new preprint on bioRXiv describes the development of a structurally realistic 3D computational model of a cardiomyocyte which we use to simulate reaction-diffusion of calcium release from RyR clusters during the initial phase of the cardiac calcium transient. We use … Continue reading

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The impact of mitochondrial organisation on heart cell bioenergetics – published in PLoS Computational Biology

Heart cells contain a high volume of mitochondria, which are necessary to generate the ATP energy supply that is needed to sustain normal heart function. Previously, mitochondria were understood to be arranged in a regular, crystalline pattern in heart cells … Continue reading

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Congratulations to Matt Faria – best paper award

Congratulations to Matt Faria – winner of a Best Paper award at the CNBS annual meeting for his paper ‘Minimum Information Reporting in Bio–Nano Experimental Literature’ Nature Nanotechnology 13, 777–785 (2018) http://doi.org/10.1038/s41565-018-0246-4

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New Preprint: Maintaining the stem cell niche in multicellular models of epithelia

Claire Miller’s new preprint is available now on arXiv. https://arxiv.org/abs/1811.10781 In epithelial tissues such as skin, stem cells divide in order to replace cells that are lost at the surface. The maintenance of the stem cell niche is therefore an … Continue reading

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