Bond graph modelling of the cardiac action potential – published in Proceedings of the Royal Society A

Our paper on modelling the cardiac action potential using an energy-based bond graph approach has now appeared in Proc R Soc Lond A. Mathematical models of cardiac action potentials have become increasingly important in the study of heart disease and pharmacology, but concerns linger over their robustness during long periods of simulation, in particular due to issues such as model drift and non-unique steady states. In this paper we develop a general and systematic method of identifying hidden conservation laws that are responsible for these undesirable characteristics in models of cardiac electrophysiology.

M. Pan, P.J. Gawthrop, K. Tran, J. Cursons, E.J. Crampin (2018)
Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states
Proceedings of the Royal Society A 474: 20180106
arXiv:1802.04548

Congratulations to Michael and coauthors!

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Congratulations to Dr Matt Faria

Congratulations to Matt Faria, who has been awarded his PhD at the Systems Biology Lab and the Caruso group at the University of Melbourne, for his thesis entitled “Quantifying interactions between nanoengineered particles and cells”.

In his thesis, Matt introduced new techniques for quantifying interactions between engineered nanomaterials and biological cells. Using a combination of experimental approaches and mathematical methods, his work isolated the kinetics of cell-particle interactions independent of experimental details.

Well done Matt!

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Systems Biology Lab presentations at Biophysics 2018

Michael Pan, Hilary Hunt, Claire Miller and Shourya Ghosh all presented their work at the recent Biophysical Society Annual Meeting in San Francisco. Well done all!

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Congratulations to Dr Greg Bass!

Congratulations to Greg Bass, who has been awarded his PhD for his thesis entitled “Decoding calcium signalling crosstalk in cardiac hypertrophy”. Greg investigated calcium signalling in heart muscle cells using imaging data and mathematical models. He showed that two distinct messages can be conveyed simultaneously by modifying the shape of the calcium curve, providing clues for how calcium signals may be encoded and decoded in many cell types.

Well done Greg!

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Congratulations to Kenneth Tran

Congratulations to our colleague and former team member Dr Kenneth Tran, from the University of Auckland who, along with Dr Andrew Taberner and Prof Edmund Crampin, has been awarded a grant from the Marsden Fund (Royal Society of New Zealand) to develop a model of heart failure in diabetes.

RSNZ Marsden fund announcement is here.

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New Postdoctoral Research Fellows

We are delighted to welcome postdoctoral research fellows Dr Agnė Tilūnaitė and Dr Pete Cudmore to the Systems Biology Lab!

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Funding Success: ARC LIEF 2018

We are pleased to announce successful ARC Linkage Infrastructure, Equipment and Facilities (LIEF) funding worth $639,369 to a team from the ARC Centre of Excellence in BioNano Science, including SBL Director Professor Edmund Crampin.  The funding will support a nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies, including an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions. 

Further details in the announcement here.

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